Search results for " cellular Stress"

showing 3 items of 3 documents

Dietary restriction: could it be considered as speed bump on tumor progression road?

2016

Dietary restrictions, including fasting (or long-term starvation), calorie restriction (CR), and short-term starvation (STS), are considered a strong rationale that may protect against various diseases, including age-related diseases and cancer. Among dietary approaches, STS, in which food is not consumed during designed fasting periods but is typically not restricted during designated feeding periods, seems to be more suitable, because other dietary regimens involving prolonged fasting periods could worsen the health conditions of cancer patients, being they already naturally prone to weight loss. Until now, the limited amount of available data does not point to a single gene, pathway, or …

0301 basic medicinemedicine.medical_specialtySettore MED/06 - Oncologia MedicaCalorie restrictionCancer cellBiologyBioinformaticsCellular stress response03 medical and health sciencesWeight lossNeoplasmsCellular stress responseInternal medicinemedicineAnimalsHumansChemotherapyShort-term starvationSettore MED/49 - Scienze Tecniche Dietetiche ApplicateCaloric RestrictionStarvationCancerCancer cells; Cellular stress response; Chemotherapy; Diet; Fasting; Short-term starvationFastingGeneral Medicinemedicine.diseaseDietSettore MED/18 - Chirurgia Generale030104 developmental biologyEndocrinologyTumor progressionCancer cellSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioSignal transductionmedicine.symptomTumor Biology
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Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals

2021

Abstract Mediterranean diet (MedDiet) is rich in fruits and vegetables associated with longevity and a reduced risk of several age-related diseases. It is demonstrated that phytochemicals in these plant products enhance the positive effects of MedDiet by acting on the inflammatory state and reducing oxidative stress. Evidence support that these natural compounds act as hormetins, triggering one or more adaptive stress-response pathways at low doses. Activated stress-response pathways increase the expression of cytoprotective proteins and multiple genes that act as lifespan regulators, essential for the ageing process. In these ways, the hormetic response by phytochemicals such as resveratro…

AgingMediterranean dietmedia_common.quotation_subjectLongevityPhytochemicalsResveratrolBiologymedicine.disease_causeDiet MediterraneanHealthy Agingchemistry.chemical_compoundHormesisStress PhysiologicalMediterranean dietmedicineHumansFood sciencemedia_commonCellular stress-response pathwaysAgeing; Cellular stress-response pathways; Hormesis; Mediterranean diet; PhytochemicalsLow doseHormesisLongevityAgeingchemistryAgeingHealthy ageingOxidative stressDevelopmental Biology
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The HDAC inhibitor SAHA synergistically stimulates the cytotoxic effect induced by Parthenolide in MDA-MB231 cells

2014

We showed that the sesquiterpene lactone Parthenolide (PN) exerts strong cytotoxic effects on triple negative breast cancer MDA-MB231 cells. Our recent results suggest that PN exerts in these cells a cytoprotective effect, which is due to the activation of mTOR pathway. To inhibit this protective response we employ the HDAC inhibitor SAHA, which is known to prevent AKT/mTOR pathway. We show that PN activates Akt, mTOR, p70S6kinase and NRF2 while SAHA abolishes these effects. Further cell pretreatment with SAHA synergistically sensitizes the cells to the cytotoxic effect of PN. Moreover SAHA alone activates the autophagic process. The addition of PN to SAHA reduces this effect and induces ap…

Parthenolide cellular Stress apoptosis autophagy triple negative breast cancer cells HDAC inhibitor.
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